Skip to main content
Fig. 3 | Molecular Medicine

Fig. 3

From: Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice

Fig. 3

Deficiency in CIRP prevented the decreased spatial cognition observed in the WT mice after binge alcohol. a Scheme for the object-place memory (OPM) task in which a mouse explores two objects, with one object being moved in the last session. b Total time exploring both objects during sample phase and test phases. c Left, representative heat maps of WT and CIRP−/− mice exploring the moved object, Right, discrimination ratio (moved minus stable object over moved plus stable object [(M-S)/(M + S)]) between WT and CIRP−/− mice at pre-alcohol and post-alcohol conditions. Data are expressed as mean ± SE; * P < 0.05; ** P < 0.005 by t-test

Back to article page

Molecular Medicine

ISSN: 1528-3658