Table 5 Regional metabolic activity in regions identified by the two way ANOVA analysis. Percent changes in regional metabolic activity in the WT and CIRP−/− mice treated with alcohol or normal saline (mean ± SE). ** P < 0.01 between pre- and post-saline treatment within groups
Regions | Anatomical Regions | Alcohol | Saline | ||||
|---|---|---|---|---|---|---|---|
WT (% change) | KO (% change) | P | WT (% change) | KO (% change) | P | ||
R1 | Olfactory bulb, glomerular layer | −14.5 ± 5.1 | 5.2 ± 3.1 | 0.004 | 13.1 ± 12.4 | 10.5 ± 12.2 | 0.89 |
R2 | Agranular insular cortex, ventral part | −10.1 ± 4.0 | 4.7 ± 2.0 | 0.002 | −5.8 ± 4.8 | 4.7 ± 3.8 | 0.13 |
R3 | Cerebellum, third lobule of cerebellar vermis | 1.5 ± 2.9 | 12.3 ± 2.1 | 0.006 | −0.3 ± 4.8 | 10.3 ± 5.4 | 0.18 |
R4 | Posteriomedial cortical amygdaloid area | −11.3 ± 5.5 | 3.1 ± 3.2 | 0.03 | 1.2 ± 3.8 | 2.1 ± 6.4 | 0.91 |
R5 | Hippocampus, fimbria | −5.3 ± 2.5 | 5.1 ± 2.1 | 0.004 | 2.8 ± 4.0 | 1.1 ± 3.4 | 0.75 |
R6 | Primary visual cortex | −18.6 ± 5.1 | −1.1 ± 4.8 | 0.022 | 4.2 ± 5.5 | 14.4 ± 8.2 | 0.1 |
R7 | Primary somatosensory cortex, barrel field | −8.5 ± 2.3 | 2.1 ± 2.5 | 0.006 | −10.0 ± 0.9* | −6.6 ± 3.1 | 0.34 |