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Table 5 Regional metabolic activity in regions identified by the two way ANOVA analysis. Percent changes in regional metabolic activity in the WT and CIRP−/− mice treated with alcohol or normal saline (mean ± SE). ** P < 0.01 between pre- and post-saline treatment within groups

From: Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice

Regions Anatomical Regions Alcohol Saline
WT (% change) KO (% change) P WT (% change) KO (% change) P
R1 Olfactory bulb, glomerular layer −14.5 ± 5.1 5.2 ± 3.1 0.004 13.1 ± 12.4 10.5 ± 12.2 0.89
R2 Agranular insular cortex, ventral part −10.1 ± 4.0 4.7 ± 2.0 0.002 −5.8 ± 4.8 4.7 ± 3.8 0.13
R3 Cerebellum, third lobule of cerebellar vermis 1.5 ± 2.9 12.3 ± 2.1 0.006 −0.3 ± 4.8 10.3 ± 5.4 0.18
R4 Posteriomedial cortical amygdaloid area −11.3 ± 5.5 3.1 ± 3.2 0.03 1.2 ± 3.8 2.1 ± 6.4 0.91
R5 Hippocampus, fimbria −5.3 ± 2.5 5.1 ± 2.1 0.004 2.8 ± 4.0 1.1 ± 3.4 0.75
R6 Primary visual cortex −18.6 ± 5.1 −1.1 ± 4.8 0.022 4.2 ± 5.5 14.4 ± 8.2 0.1
R7 Primary somatosensory cortex, barrel field −8.5 ± 2.3 2.1 ± 2.5 0.006 −10.0 ± 0.9* −6.6 ± 3.1 0.34