Fig. 1

Regression of CA injury-induced neointimal hyperplasia in ApoE KO mice by Fimasartan administration. a Chemical structure of fimasartan (2-n-butyl-5-dimethylamino-thiocarbonyl-methyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}pyrimidin-4(3H)-one). b Schematic depiction of the study protocol. c Representative H&E-stained images of the CA cross sections of ApoE KO mice. Boxed regions were magnified in the under panels. Scale bar: 100 μm. d Quantitative analysis of the incidence of neointimal hyperplasia areas in CA after CA injury and/or fimasartan administration. Data shown represent mean ± SD on 40 sections (two fields per section, two sections per CA, n = 10 for each group). *p < 0.05. e Representative immunofluorescence images and quantitative analysis results showing CD68⁺ macrophage (red) expression in CA at 28 days after CA injury and/or fimasartan administration. White arrows indicate CD68⁺ macrophages in CA. Nuclei were stained with DAPI. Scale bar: 100 μm. *p < 0.05. All experimental data are from n = 10 of ApoE KO mice in each group