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Fig. 4 | Molecular Medicine

Fig. 4

From: FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

Fig. 4

FBXW7 suppresses the expression and release of HMGB1 in HFD-fed mouse livers. a Serum HMGB1 levels in different treatment groups (n = 5). b and (e) Immunoblotting and densitometry of HMGB1 in mouse livers (n = 4). c and (f) Immunohistochemistry staining of HMGB1 in mouse livers (n = 4). d Immunoblotting and densitometry of FBXW7 in mouse livers (n = 4). Magnification 200X. All of the values are expressed as the mean ± SD. **P < 0.01, ***P < 0.001 versus the ND + Ad-GFP group; ##P < 0.01, ###P < 0.001 versus the HFD + Ad-GFP group; && P < 0.01 versus the HFD + shScramble group

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Molecular Medicine

ISSN: 1528-3658