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Fig. 7 | Molecular Medicine

Fig. 7

From: FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

Fig. 7

Exogenous HMGB1 abolishes FBXW7 overexpression-mediated improvement of insulin resistance and inflammation in HFD-fed mouse livers. a Serum HMGB1 levels in different treatment groups (n = 4). b Data of glucose tolerance tests in different treatment groups (n = 4). c Data of insulin tolerance tests in different treatment groups (n = 4). d Immunoblotting and densitometry of p-Akt in mouse livers (n = 4). e Immunoblotting and densitometry of p-GSK3β in mouse livers (n = 4). f Representative confocal immunofluorescence images of F4/80 (red) and DAPI (blue) in mouse livers (n = 4). g The mRNA level of inflammation-related genes in mouse livers (n = 3). All of the values are expressed as the mean ± SD. **P < 0.01, ***P < 0.001 versus the HFD + Ad-FBXW7 group

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