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Fig. 8 | Molecular Medicine

Fig. 8

From: FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

Fig. 8

Exogenous HMGB1 abates FBXW7 overexpression-mediated inhibition of TLR4 and RAGE signaling in HFD-fed mouse livers (n = 4). a Representative confocal immunofluorescence images of TLR4 (yellow), F4/80 (red) and DAPI (blue) in mouse livers. b Immunoblotting and densitometry of the components of TLR4 signaling in mouse livers. c Representative confocal immunofluorescence images of RAGE (yellow), F4/80 (red) and DAPI (blue) in mouse livers. d Immunoblotting and densitometry of the components of RAGE signaling in mouse livers. All of the values are expressed as the mean ± SD. **P < 0.01 versus the versus the HFD + Ad-FBXW7 group

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Molecular Medicine

ISSN: 1528-3658