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Fig. 6 | Molecular Medicine

Fig. 6

From: Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

Fig. 6

R16/17 protein transfer improves blood perfusion of the contracting muscle. Blood flow of the TA muscles was measured by microsphere deposition and the flow probe reading. The linear regression model was established by plotting the values from the contracting muscle against those from the resting muscle. Statistical analysis was performed to compare the slopes of three experimental groups: mdx4cv mice, ΔR4 mice without R16/17 protein transfer and ΔR4 mice with R16/17 protein transfer. *: ΔR4 mice treated with R16/17 protein showed a slope that was significantly higher than the other two groups, indicating improved perfusion in the contracting TA muscle in this group of mice

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