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Fig. 1 | Molecular Medicine

Fig. 1

From: FOXD1 mutations are related to repeated implantation failure, intra-uterine growth restriction and preeclampsia

Fig. 1

Transactivation properties of FOXD1-WT and mutant versions on C3 and PlGF promoters. The FOXD1-WT version overexpression allowed to transactivate the C3 and PlGF promoters in luciferase gene reporter assays (C3: WT vs empty vector, 1.9-fold, p = 0.0024; PlGF: WT vs empty vector, 3-fold, p = 1.3 × 10− 5) (a and b panels). a Compared to that of the WT version, the FOXD1 p.His267Tyr and p.Arg57del mutations increased significantly C3 transcriptional activity (1.25-fold, p = 0.03 and 1.5-fold, p = 0.0004, respectively). b The FOXD1-p.Arg57del mutation increased PlGF transcriptional activity (1.4 fold, p = 0.002) compared to that for the FOXD1-WT counterpart. RLU: relative luciferase units. (*): p < 0.05; (***): p < 0.001

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Molecular Medicine

ISSN: 1528-3658