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Table 2 Comparison of CARDS toxin and cytokines in BALF from control and MPP (including RMPP and NRMPP) children

From: High co-expression of TNF-α and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia

CARDS toxin and cytokines in BALF MPP cases
(n = 71)
Controls
(n = 22)
P value RMPP
(n = 21)
NRMPP
(n = 50)
P value
CARDS toxin, relative expression 12.5 (4.9–31.1) 0.5 (0.2–1.4) < 0.001 19.6 (9.0–63.0) 10.0 (3.1–25.5) 0.025
TNF-α, pg/ml 68 ± 12.7 40.4 ± 6.2 < 0.001 76.9 ± 11.2 64.2 ± 11.4 < 0.001
IFN-γ, pg/ml 541.2 ± 104.1 357.3 ± 83.3 < 0.001 535.6 ± 96.9 543.5 ± 104.8 0.772
IL-36, pg/ml 429.9 ± 60.6 360.5 ± 61.2 < 0.001 438.8 ± 61.6 426.5 ± 60.5 0.457
IL-17, pg/ml 23.6 ± 5.6 24.7 ± 5.4 0.428 23.6 ± 5.4 23.6 ± 5.8 0.986
IL-8, pg/ml 67 ± 15.0 52.2 ± 14.7 < 0.001 65.4 ± 14.7 67.7 ± 15.2 0.584
IL-6, pg/ml 24.7 ± 5.7 16.1 ± 4.0 < 0.001 28.1 ± 3.8 23.2 ± 5.8 < 0.001
IL-4, pg/ml 66.8 ± 14.6 36.4 ± 6.5 < 0.001 68.7 ± 12.5 66.0 ± 15.4 0.477
  1. RMP refractory Mycoplasma pneumoniae pneumonia, NRMPP non-refractory Mycoplasma pneumoniae pneumonia, CARDS toxin community-acquired respiratory distress syndrometoxin, BALF bronchoalveolar lavage fluid, TNF-α tumor necrosis factor-α, IFN-γ interferon-γ, IL-36 interleukin-36, IL-17 interleukin-17, IL-8 interleukin-8, IL-6 interleukin-6, IL-4 interleukin-4