Table 2 Comparison of CARDS toxin and cytokines in BALF from control and MPP (including RMPP and NRMPP) children
CARDS toxin and cytokines in BALF | MPP cases (n = 71) | Controls (n = 22) | P value | RMPP (n = 21) | NRMPP (n = 50) | P value |
|---|---|---|---|---|---|---|
CARDS toxin, relative expression | 12.5 (4.9–31.1) | 0.5 (0.2–1.4) | < 0.001 | 19.6 (9.0–63.0) | 10.0 (3.1–25.5) | 0.025 |
TNF-α, pg/ml | 68 ± 12.7 | 40.4 ± 6.2 | < 0.001 | 76.9 ± 11.2 | 64.2 ± 11.4 | < 0.001 |
IFN-γ, pg/ml | 541.2 ± 104.1 | 357.3 ± 83.3 | < 0.001 | 535.6 ± 96.9 | 543.5 ± 104.8 | 0.772 |
IL-36, pg/ml | 429.9 ± 60.6 | 360.5 ± 61.2 | < 0.001 | 438.8 ± 61.6 | 426.5 ± 60.5 | 0.457 |
IL-17, pg/ml | 23.6 ± 5.6 | 24.7 ± 5.4 | 0.428 | 23.6 ± 5.4 | 23.6 ± 5.8 | 0.986 |
IL-8, pg/ml | 67 ± 15.0 | 52.2 ± 14.7 | < 0.001 | 65.4 ± 14.7 | 67.7 ± 15.2 | 0.584 |
IL-6, pg/ml | 24.7 ± 5.7 | 16.1 ± 4.0 | < 0.001 | 28.1 ± 3.8 | 23.2 ± 5.8 | < 0.001 |
IL-4, pg/ml | 66.8 ± 14.6 | 36.4 ± 6.5 | < 0.001 | 68.7 ± 12.5 | 66.0 ± 15.4 | 0.477 |