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Table 3 Significantly enriched BP GO terms in active protein modules of DCresistant sub-network

From: Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia

BP GO term Count FDR corrected P-value
Turquoise module
 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 33 1.05E-58
 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 32 2.26E-57
 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 32 3.66E-57
 positive regulation of protein ubiquitination 34 1.08E-54
 ubiquitin-dependent protein catabolic process 36 9.37E-41
 proteolysis 37 3.94E-27
Brown module
 mitochondrial ATP synthesis coupled electron transport 12 1.82E-17
 mitochondrial electron transport, NADH to ubiquinone 11 4.66E-17
 respiratory electron transport chain 12 5.11E-17
 electron transport chain 13 9.51E-16
 oxidative phosphorylation 12 9.11E-15
 mitochondrion organization 6 1.17E-04
Yellow module
 positive regulation of programmed cell death 9 2.59E-03
 MAPKKK cascade 6 2.59E-03
 protein amino acid phosphorylation 10 2.59E-03
 response to stimulus 24 2.59E-03
 programmed cell death 9 3.68E-03
Green module
 RNA splicing 8 6.09E-05
 regulation of acetyl-CoA biosynthetic process from pyruvate 3 1.31E-04
 spliceosomal snRNP assembly 3 1.61E-03
 response to DNA damage stimulus 7 1.80E-03
 nuclear mRNA splicing, via spliceosome 4 1.92E-03
 glycolysis 3 3.52E-03
Red module
 tRNA aminoacylation 8 1.50E-11
 tRNA aminoacylation for protein translation 8 1.50E-11
 translation 9 1.88E-06
Pink module
 fatty acid oxidation 6 7.26E-10
 peroxisome organization 5 3.55E-09
 protein targeting to peroxisome 3 1.37E-05
 fatty acid beta-oxidation using acyl-CoA oxidase 2 2.84E-04
 acyl-CoA metabolic process 2 1.94E-03
 mitochondrion organization 3 4.30E-03