Fig. 7
From: Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis
Melatonin improves bone metabolism in osteoporosis (OP) mice. Laboratory tests for biochemical markers of bone metabolism. Serum bone metabolism-related indicators RANKL (a), TRACP (b), OPG (c), ALP (d), phosphorus (e), calcium (f), and urinary phosphorus (g) and calcium (h) were determined after the administration of melatonin or alendronate for 2 months. Control: normal mice, Model: retinoic acid (RA)-induced OP model mice, Mlt-L: low-dose melatonin-treated OP model mice, Mlt-H: high-dose melatonin-treated OP model mice. Positive control: alendronate-treated OP mice. *, P < 0.05 vs control. #, P < 0.05 vs model; n = 6 per group