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Fig. 1 | Molecular Medicine

Fig. 1

From: Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue

Fig. 1

Light microscopy images demonstrating the specificity of HER2 affibody-QD labelling on tumour sections. The images represent an overlay of the fluorescence signal and the direct interference contrast (DIC) signal, providing a three-dimensional impression of the sample surfaces, and the red colour originating from the QD655’s fluorescence. a A tumour section exhibiting red fluorescence signals deriving from the HER2-bound QDs. The cell shapes are visible from the DIC signal in grey. b Example of a negative control experiment, performed with another section from the same tumour, and the same labelling protocol, except that the HER2 Affibody incubation was omitted. The exposure settings of the fluorescence channel were the same for both images. Scale bars 50 μm

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