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Fig. 1 | Molecular Medicine

Fig. 1

From: Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

Fig. 1

XOR activity assays and XOR expression in kidney lysates. XOR activity was not detected in kidney lysates of all XOR inhibitor-treated groups. a XDH and XO activity in vehicle-treated rats did not change during I/R injury. b XDH/XO ratios were not altered throughout I/R. c XOR expression in kidney lysates was detected as a 150-kDa single band in each group by western blotting. M, molecular markers; 1–3, vehicle-treated rats; 4–6, febuxostat-treated rats; 7–9, topiroxostat-treated rats; 10–12, allopurinol-treated rats. Samples in lanes 1, 4, 7, and 10 are kidney samples in the stationary state; those in lanes 2, 5, 8, 11 are at 30 min ischemia injury; and those in lanes 3, 6, 9, 12 are at 30 min of reperfusion after 30 min of ischemia injury

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Molecular Medicine

ISSN: 1528-3658