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Table 1 Overview of the experimental set-up and plasma biochemical data

From: Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury

  Veh-S Feb-S Top-S Allo-S Veh-I Feb-I Top-I Allo-I Veh-R Feb-R Top-R Allo-R
Sampling state Stationary (under resting state) 30 min left renal ischemia 30 min left renal ischemia + 30 min reperfusion
Administrated drugs 0.5% Methyl-cellulose 10 mg/kg Febu-xostat 10 mg/kg Topiro-xostat 50 mg/kg Allo-purinol 0.5% Methyl-cellulose 10 mg/kg Febu-xostat 10 mg/kg Topiro-xostat 50 mg/kg Allo-purinol 0.5% Methyl-cellulose 10 mg/kg Febu-xostat 10 mg/kg Topiro-xostat 50 mg/kg Allo-purinol
Identification of group
BUN (mg/dl) 16.8 ± 1.6 12.8 ± 1.0 14.7 ± 2.5 16.1 ± 1.4 21.4 ± 2.9 $$,&&,## 20.2 ± 2.1 $$,&&,# 20.1 ± 3.0 $$,&&,## 21.9 ± 3.2 *,$$,&&,## 20.2 ± 2.0 $$,&&,# 20.3 ± 0.7 $$,&&,# 20.5 ± 2.9 $$,&&,# 21.2 ± 1.7 *,$$,&&,##
Creatinine (mg/dl) 0.26 ± 0.03 0.28 ± 0.03 0.30 ± 0.03 0.28 ± 0.04 0.41 ± 0.04 **,$$,&,## 0.39 ± 0.05 **,$$,&,## 0.41 ± 0.05 **,$$,&&,## 0.43 ± 0.09 **,$$,&&,## 0.39 ± 0.05 **,$$,&,## 0.37 ± 0.05 **,$,## 0.45 ± 0.04 **,$$,&&,## 0.43 ± 0.06 **,$$,&&,##
Uric Acid (mg/dl) 0.46 ± 0.17 0.1 > ±N.A 0.1 > ±N.A 0.1 > ±N.A 0.63 ± 0.14* 0.1 0.1 > ±N.A 0.1 > ±N.A 0.54 ± 0.05 0.1 0.1 > ±N.A 0.1
  1. BUN, blood urea nitrogen. Concentrations are expressed as nmol/g wet weight; the data are represented as the mean ± SEM (n = 5/6). *P < 0.05 and **P < 0.01 versus Veh-S; $P < 0.05 and $$P < 0.01 versus Feb-S; &P < 0.05 and &&P < 0.01 versus Top-S; #P < 0.05 and ##P < 0.01 versus Allo-S; one-way ANOVA followed by Games–Howell’s test