Fig. 1
From: PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer
PRSS1 mutation screening and sequencing. a. Screening processes; b. Results of whole-exome sequencing screening: gray (all mutations; green (mutations following certain inheritance patterns), blue (likely detrimental mutations), red (mutations located in the PRSS1 gene sequence); c. PRSS1 exon mutation frequency and associations of mutations with serum trypsin levels; d. Sanger sequencing to confirm the R116C mutation; e. R116C mutation at a relatively stable site in species; f. PRSS1_R116C mutation could elicit protein misfolding and conformational disorder of trypsinogen; g. PRSS1_R116C mutation upregulated trypsin expression