Fig. 3
From: PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer
PRSS1_R116C enhances malignant phenotypes in pancreatic cancer via the JAK1/STAT5 pathway. a. Trypsin was co-localized with PAR2; b. Effect of PRSS1_R116C mutant/PRSS1 wild type overexpression on trypsin and PAR2 expression levels. c. RNA-seq was performed to assess the mRNA expression levels of critical proteins in the JAK-STAT pathway; d. qRT-PCR was applied to confirm the mRNA levels of critical proteins in the JAK1-STAT5 pathway; e. Western blot measurement of tumor relevant proteins