Fig. 3

WGCNA analysis of the differentially expressed genes and Gene ontology enrichment analysis and KEGG pathway analysis of the functioned modules (a) Gene clustering and module identification was made by WGCNA analysis on the basis of the gene chip-GSE28735. Cluster dendrogram diaplayed the result of hierarchical clustering, and each line represented a gene. The colored column below the dendrogram represented module conducted by the static tree cutting method. The blue and turquoise color show different co-expression network modules for DEGs and grey module represents insignificant module. b-c Gene ontology enrichment analysis and KEGG pathway enrichment analysis of turquoise (b) and blue (c) module. The vertical axis represented GO term or pathway, and the horizontal axis represented count of genes. The value of false discovery rate was shown at the end of each column. BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto encyclopedia of genes and genomes; WGCNA, weighted gene co-expression network analysis