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Fig. 2 | Molecular Medicine

Fig. 2

From: Recombinant human milk fat globule-EGF factor VIII (rhMFG-E8) as a therapy for sepsis after acute exposure to alcohol

Fig. 2

rhMFG-E8 reduces systemic inflammation and bacteremia in CLP after acute alcohol exposure. Levels of (a) serum TNF-α, (b) serum IL-6, and (c) serum endotoxin were increased rats subjected to CLP and treated with vehicle (human albumin) compared with sham surgery, and lower in rats subjected to CLP and treated with rhMFG-E8. Prior to CLP, all rats were exposed to acute alcohol intoxication; means + SE; n = 10–14 for sham and n = 9 for other experimental groups; ANOVA plus Student-Newman-Keuls method, * P < 0.05 vs. Sham, # P < 0.05 vs. Vehicle

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Molecular Medicine

ISSN: 1528-3658