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Fig. 6 | Molecular Medicine

Fig. 6

From: Recombinant human milk fat globule-EGF factor VIII (rhMFG-E8) as a therapy for sepsis after acute exposure to alcohol

Fig. 6

rhMFG-E8 improves the survival rate in CLP after acute alcohol exposure. The 10-day survival rate of rats subjected to CLP and treated with 20 μ/kg BW rhMFG-E8 was significantly higher than that of rats subjected to CLP and treated with vehicle (20 μ/kg BW human albumin). The survival benefit of animals treated with rhMFG-E8 was similar to that of animals treated with 20 μ/kg BW rmMFG-E8. Prior to CLP, all rats were exposed to acute alcohol intoxication; CLP was attenuated by surgical excision of the gangrenous cecum and peritoneal cavity irrigation at 20 h after CLP; n = 18 for rhMFG-E8 and n = 20 for other experimental groups); Kaplan-Meier plus log-rank test, * P < 0.05 vs. Vehicle

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Molecular Medicine

ISSN: 1528-3658