| P | |||||
---|---|---|---|---|---|---|
Parameters | Control (n = 89) | Bipolar depression (n = 92) | Unipolar depression (n = 195) | Total (n = 376) | Overall | Bipolar depression vs. Unipolar depression |
Gender | 0.002 | < 0.001 | ||||
 Male | 25 (28.09) | 42 (45.65) | 49 (25.13) | 116 (30.85) |  |  |
 Female | 64 (71.91) | 50 (54.35) | 146 (74.87) | 260 (69.15) |  |  |
Age, years | 47.34 ± 13.05 | 24.76 ± 12.75* | 44.10 ± 13.94 | 40.13 ± 16.08 | < 0.001 | < 0.001 |
BMI, kg/m2 | 21.88 ± 3.14 | 21.38 ± 4.13 | 21.87 ± 2.92 | 21.76 ± 3.30 | 0.474 | 0.249 |
SBP, mmHg | 121.82 ± 16.08 | 118.36 ± 13.00 | 122.69 ± 16.68 | 121.43 ± 15.77 | 0.098 | 0.033 |
DBP, mmHg | 76.36 ± 10.27 | 73.91 ± 11.41 | 76.47 ± 10.99 | 75.82 ± 10.96 | 0.168 | 0.070 |
Biochemical parameters | ||||||
 Glucose | 4.86 ± 0.58 | 4.91 ± 1.14 | 5.11 ± 1.36 | 5.00 ± 1.17 | 0.171 | 0.184 |
 Triglycerides | 1.29 ± 0.60 | 1.05 ± 0.63 | 1.46 ± 1.21 | 1.32 ± 0.99 | 0.004 | 0.001 |
 Cholesterol | 4.65 ± 0.87 | 4.27 ± 0.98* | 4.75 ± 1.06 | 4.61 ± 1.02 | < 0.001 | < 0.001 |
 HDL | 1.17 ± 0.28 | 1.18 ± 0.29 | 1.21 ± 0.30 | 1.19 ± 0.29 | 0.508 | 0.400 |
 LDL | 2.89 ± 0.75 | 2.59 ± 0.78* | 2.90 ± 0.84 | 2.82 ± 0.81 | 0.008 | 0.003 |
 VLDL | 0.60 ± 0.23 | 0.50 ± 0.27* | 0.64 ± 0.35 | 0.60 ± 0.31 | 0.002 | < 0.001 |
 Prolactin | 33.26 ± 29.65 | 51.20 ± 63.75* | 38.73 ± 35.95 | 40.67 ± 44.08 | 0.021 | 0.029 |
 T4 | 7.62 ± 1.55 | 7.04 ± 1.69* | 7.28 ± 1.58 | 7.30 ± 1.61 | 0.071 | 0.266 |
 FT4 | 1.12 ± 0.18 | 1.19 ± 0.21* | 1.17 ± 0.19 | 1.16 ± 0.19 | 0.048 | 0.293 |
 T3 | 0.93 ± 0.19 | 0.94 ± 0.20 | 0.88 ± 0.18* | 0.91 ± 0.19 | 0.022 | 0.017 |
 FT3 | 3.03 ± 0.40 | 3.28 ± 0.49* | 2.96 ± 0.40 | 3.06 ± 0.45 | < 0.001 | < 0.001 |
 TSH | 1.98 ± 1.63 | 1.99 ± 1.47 | 2.23 ± 3.47 | 2.11 ± 2.73 | 0.698 | 0.493 |
 Cortisol | 15.50 ± 6.39 | 17.11 ± 8.09 | 17.68 ± 7.78* | 17.02 ± 7.59 | 0.104 | 0.562 |
 Insulin resistance | 1.23 ± 0.79 | 0.99 ± 0.77 | 1.40 ± 1.61 | 1.26 ± 1.29 | 0.043 | 0.012 |
Psychological index | ||||||
 Anhedonia | < 0.001 | 0.003 | ||||
  No | 62 (72.94) | 34 (38.20) | 40 (21.28) | 136 (37.57) |  |  |
  Yes | 23 (27.06) | 55 (61.80) | 148 (78.72) | 226 (62.43) |  |  |
 Suicidal thoughts | < 0.001 | 0.143 | ||||
  No | 78 (91.76) | 51 (57.30) | 90 (47.87) | 219 (60.50) |  |  |
  Yes | 7 (8.24) | 38 (42.70) | 98 (52.13) | 143 (39.50) |  |  |