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Table 3 Logistic regression and ROC analysis results

From: Comparison of blood lipid profile/thyroid function markers between unipolar and bipolar depressed patients and in depressed patients with anhedonia or suicidal thoughts

 

Logistic regression

(Crude)

Logistic regression

(Adjusted d)

ROC analysis

Parameters

OR (95% CI)

P

OR (95% CI)

P

AUC (95% CI)

P

Bipolar depression (as reference) vs. Unipolar depression a

 Gender

  Male

ref.

–

ref.

–

–

–

  Female

2.50 (1.48–4.22)

< 0.001

1.48 (0.75–2.91)

0.260

–

–

 Age, year

1.10 (1.08–1.13)

< 0.001

1.10 (1.07–1.13)

< 0.001

–

–

 SBP, mmHg

1.02 (1.00–1.04)

0.033

1.00 (0.97–1.02)

0.824

0.551 (0.479–0.623)

0.177

 Triglycerides

1.82 (1.21–2.73)

0.004

1.28 (0.84–1.95)

0.249

0.620 (0.550–0.689)

0.001

 Cholesterol

1.60 (1.23–2.09)

< 0.001

1.31 (0.28–6.05)

0.732

0.633 (0.563–0.703)

< 0.001

 LDL

1.64 (1.17–2.29)

0.004

0.95 (0.62–1.45)

0.797

0.611 (0.540–0.682)

0.003

 VLDL

4.72 (1.85–12.05)

0.001

1.40 (0.30–6.47)

0.666

0.626 (0.557–0.696)

< 0.001

 Prolactin

0.99 (0.99–1.00)

0.060

0.99 (0.99–1.00)

0.092

0.546 (0.470–0.622)

0.238

 T3

0.19 (0.05–0.76)

0.019

0.62 (0.11–3.36)

0.577

0.598 (0.522–0.675)

0.012

 FT3

0.19 (0.10–0.37)

< 0.001

0.73 (0.32–1.66)

0.453

0.685 (0.613–0.758)

< 0.001

 Insulin resistance

1.41 (1.04–1.92)

0.028

0.51 (0.18–1.47)

0.214

0.588 (0.517–0.659)

0.019

Anhedonia b

 LDL

0.72 (0.52–1.00)

0.049

0.64 (0.45–0.91)

0.013

0.560 (0.482–0.638)

0.129

Suicidal thoughts c

 Cholesterol

1.28 (1.02–1.62)

0.037

1.30 (1.01–1.67)

0.043

0.589 (0.522–0.657)

0.011

 HDL

4.71 (1.97–11.27)

< 0.001

3.81 (1.55–9.33)

0.003

0.636 (0.571–0.702)

< 0.001

  1. adependent variable was diagnosis, including only bipolar depression and unipolar depression patients where bipolar depression as compared reference
  2. b dependent variable was anhedonia (no or yes), ‘no’ as reference
  3. c dependent variable was Suicidal thoughts (no or yes), ‘no’ as reference
  4. d Depression model was adjusted with patient’s age, gender, triglyceridess, HDL and LDL cholesterol; anhedonia and suicidal thoughts models was adjusted with patient’s age and gender
  5. HDL high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol, VLDL very low-density lipoprotein cholesterol; T3 triiodothyronine; FT3, free T3; FT4, free T4; TSH thyroid-stimulating hormone