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Fig. 3 | Molecular Medicine

Fig. 3

From: Long non-coding RNA MCM3AP-AS1 promotes growth and migration through modulating FOXK1 by sponging miR-138-5p in pancreatic cancer

Fig. 3

MCM3AP-AS1 knockdown inhibited cell growth and invasion in PC cells, and suppressed tumor growth in mice. a qRT-PCR was used to measure MCM3AP-AS1 level. b Cell proliferation was detected using MTT assay. c Clone formation assay was used to measure clone formation ability. d-e Cell invasion and migration was examined by Transwell assay and wound healing assay. Scale bar: 50 μm. f Western blot analysis detected PCNA, MMP2, MMP9 and p21 protein levels. n = 3. g Tumor volume and weight were examined. h Immunohistochemical staining testified Ki67 expression. Scale bar: 50 μm. (**, p < 0.01)

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Molecular Medicine

ISSN: 1528-3658