Fig. 1

Hyperoxia-induced BPD mouse models are successfully established. A, Body weight of neonatal mice under exposure of RA or hyperoxia. B, HE staining of lung tissues of neonatal mice under exposure of RA or hyperoxia (× 400). C, Alveolar cavity area in lung tissues in neonatal mice under exposure of RA or hyperoxia. D, Alveolar chord length in lung tissues in neonatal mice under exposure of RA or hyperoxia. E, RAC in lung tissues of neonatal mice under exposure of RA or hyperoxia. N = 15. ^* p < 0.05 vs. the neonatal mice under RA exposure (the RA group). Measurement data were expressed as mean ± standard deviation. Data comparison between two groups was examined by unpaired t-test. Comparison of data at different time points was examined by repeated-measures analysis of variance. BPD, bronchopulmonary dysplasia; RA, room air; HE, hematoxylin-eosin; RAC, radial alveolar counts