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Table 1 Changes in echocardiographic findings during the study

From: Cardioprotective effects of genetically engineered cardiac stem cells by spheroid formation on ischemic cardiomyocytes

Days

Variables

Sham (n = 4)

Adherent CSCs (n = 5)

Sphere CSCs (n = 5)

Day 1

IVSd (cm)

0.11 ± 0.04

0.10 ± 0.02

0.08 ± 0.02

LVIDd (cm)

0.69 ± 0.06

0.61 ± 0.05

0.51 ± 0.11

LVPWd (cm)

0.15 ± 0.02

0.13 ± 0.04

0.09 ± 0.04

LVIDs (cm)

0.53 ± 0.06

0.46 ± 0.05

0.37 ± 0.08

EDV (ml)

0.76 ± 0.18

0.53 ± 0.12

0.35 ± 0.19

ESV (ml)

0.36 ± 0.11

0.26 ± 0.09

0.14 ± 0.08

EF (%)

52.93 ± 5.03

52.95 ± 10.34

58.65 ± 7.62

FS (%)

23.67 ± 2.77

23.83 ± 6.20

26.90 ± 4.82

SV (ml)

0.40 ± 0.09

0.28 ± 0.08

0.21 ± 0.12

LVd mass (g)

1.03 ± 0.12

0.91 ± 0.08

0.78 ± 0.13

RWT

0.44 ± 0.09

0.41 ± 0.11

0.36 ± 0.14

Day 7

IVSd (cm)

0.09 ± 0.02

0.08 ± 0.01

0.09 ± 0.01

LVIDd (cm)

0.81 ± 0.05

0.83 ± 0.04

0.67 ± 0.14

LVPWd (cm)

0.14 ± 0.03

0.13 ± 0.02

0.12 ± 0.03

LVIDs (cm)

0.67 ± 0.06

0.66 ± 0.06

0.52 ± 0.13

EDV (ml)

0.90 ± 0.41

1.25 ± 0.16

0.74 ± 0.37

ESV (ml)

0.69 ± 0.17

0.67 ± 0.16

0.37 ± 0.19

EF (%)

40.22 ± 11.62

46.79 ± 9.14

52.09 ± 9.90

FS (%)

17.24 ± 5.90

20.64 ± 5.22

23.40 ± 5.96

SV (ml)

0.46 ± 0.17

0.58 ± 0.11

0.37 ± 0.18

LVd mass (g)

1.10 ± 0.11

1.07 ± 0.10

0.92 ± 0.12

RWT

0.32 ± 0.12

0.31 ± 0.03

0.36 ± 0.13

Day 28

IVSd (cm)

0.09 ± 0.03

0.09 ± 0.02

0.11 ± 0.07

LVIDd (cm)

0.93 ± 0.02

0.92 ± 0.07

0.80 ± 0.08

LVPWd (cm)

0.14 ± 0.04

0.15 ± 0.03

0.18 ± 0.04

LVIDs (cm)

0.67 ± 0.02

0.64 ± 0.06

0.46 ± 0.07

EDV (ml)

1.70 ± 0.10

1.66 ± 0.32

1.15 ± 0.32

ESV (ml)

0.70 ± 0.05

0.63 ± 0.19

0.26 ± 0.10

EF (%)

59.20 ± 2.15

63.85 ± 3.48

77.91 ± 4.98

FS (%)

27.82 ± 1.36

30.91 ± 2.33

42.02 ± 4.82

SV (ml)

1.01 ± 0.08

1.06 ± 0.19

0.89 ± 0.25

LVd mass (g)

0.98 ± 0.41

1.25 ± 0.19

1.24 ± 0.21

RWT

0.29 ± 0.09

0.32 ± 0.05

0.45 ± 0.15

  1. CSC Cardiac stem cell, IVDSd Interventricular septal end diastole, LVIDd Left ventricular internal diameter end diastole, LVPWd Left ventricular posterior wall end diastole, LVIDs, Left ventricular internal diameter end systole, EDV End-diastolic volume, ESV End-systolic volume, EF Ejection fraction, FS fractional shortening, SV Systolic volume, LVd mass Left ventricular mass at end diastole, RWT Relative wall thickness
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Molecular Medicine

ISSN: 1528-3658