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Fig. 5 | Molecular Medicine

Fig. 5

From: Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis

Fig. 5

a. The increased level of miR-21 in PBMCs leads to the downregulation of RASGRP1 mRNA with the concomitant decrease of DNMT1, triggering immune-driven progression of PBC. b. AMA- negative PBC patients are characterized by enhanced expression of miR-21 and miR-150. The elevated levels of serum miR-21 in AMA- negative PBC decreases gradually as liver fibrosis develops

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Molecular Medicine

ISSN: 1528-3658