TY - JOUR AU - Ottestad, William AU - Rognes, Ingrid N. AU - Skaga, Erlend AU - Frisvoll, Cassandra AU - Haraldsen, Guttorm AU - Eken, Torsten AU - Lundbäck, Peter PY - 2019 DA - 2019/12/31 TI - HMGB1 concentration measurements in trauma patients: assessment of pre-analytical conditions and sample material JO - Molecular Medicine SP - 5 VL - 26 IS - 1 AB - HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, despite that pre-analytical conditions account for a substantial part of the overall error rate in laboratory testing. We hypothesized that the considerable variations in reported HMGB1 concentrations and kinetics in trauma patients could be partly explained by differences in pre-analytical conditions and choice of sample material. SN - 1528-3658 UR - https://doi.org/10.1186/s10020-019-0131-0 DO - 10.1186/s10020-019-0131-0 ID - Ottestad2019 ER -