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Table 4 Frequency of polymorphisms in NGF and p75NTR genes in different ethnic populations

From: NGF (−198C > T, Ala35Val) and p75NTR (Ser205Leu) gene mutations are associated with liver function in different histopathological profiles of the patients with chronic viral hepatitis in the Brazilian Amazon

 

ETHNIC POPULATIONS

Gene

SNP

Alleles

AB

AB

Global

SA

AA

NA

EUR

AFR

ASI

P < 0.05

NGF

  

Ref.:

1000Genomes

The PAGE Study

The PAGE Study

The PAGE Study

1000Genomes

1000Genomes

The PAGE Study

 
 

-198C > T

C

0.461

0.567

0.532

0.535

0.638

0.489

0.344

0.685

0.540

Yes

  

T

0.539

0.433

0.468

0.465

0.362

0.511

0.656

0.315

0.460

 
   

Ref.:

 
 

Arg80Gln

Arg

0.995

0.889

0.995

0.994

0.996

0.986

0.988

1.00

1.00

Yes

  

Gln

0.005

0.111

0.005

0.006

0.004

0.014

0.012

0.00

0.00

 
   

Ref.:

 
 

Val72Met

Val

0.981

1.00

0.993

0.999

0.979

0.995

0.999

0.975

1.00

Yes

  

Met

0.019

0.00

0.007

0.001

0.121

0.005

0.001

0.025

0.00

 
   

Ref.:

 
 

Ala35Val

Ala

0.672

0.669

0.753

0.670

0.798

0.624

0.544

0.845

0.803

Yes

  

Val

0.328

0.331

0.247

0.330

0.202

0.376

0.456

0.155

0.197

 
   

Ref.:

GO Exome Sequencing Project

ExAc

 
 

Ala18Ala

Ala-C

0.990

0.98

0.955

0.881

0.999

0.837

0.999

No

  

Ala-T

0.010

0.02

0.045

0.119

0.001

0.163

0.001

 
   

Ref.:

The PAGE Study

The PAGE Study

 

p75NTR

Ser205Leu

Ser

0.944

0.938

0.947

0.962

0.985

0.963

0.936

0.995

0.898

Yes

  

Leu

0.056

0.062

0.053

0.038

0.015

0.037

0.064

0.005

0.102

 
  1. Marked cells have allele frequencies statistically similar to the infected group
  2. AB Amazonian-Brazilian population infected. AB No infected, SA South American descendent population, AA African American descendent population, NA Native American descent population, EUR European descendent population, AFR African population, ASI Asian descendant population