Skip to main content

Table 6 Results of the Pathway and GO Biological Process Enrichment Analysis of Several Important Consensus Modules

From: Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

ConsensusModulePathway/BPTermAdjusted P-value
asthma-IPFPurplePathwayExtracellular matrix organization6.81E − 06
Degradation of the extracellular matrix2.84E − 02
Collagen biosynthesis and modifying enzymes1.48E − 02
Integrin cell surface interactions2.57E − 04
Collagen formation2.14E − 02
Syndecan interactions2.14E − 02
Non-integrin membrane-ECM interactions5.91E − 02
BPextracellular matrix disassembly2.47E − 05
biofilm matrix organization2.47E − 05
basement membrane organization2.47E − 05
negative regulation of wound healing, spreading of epidermal cells3.49E − 02
extracellular matrix organization2.47E − 05
regulation of blood vessel branching5.56E − 02
asthma-COPDTurquoisePathwayAssembly of the primary cilium4.21E − 02
BPcilium assembly1.30E − 04
cilium organization1.30E − 04
plasma membrane bounded cell projection assembly6.81E − 04
cilium-dependent cell motility2.37E − 03
regulation of cilium movement2.37E − 03
COPD-IPFBluePathwayFocal adhesion7.89E − 05
Regulators of Bone Mineralization2.33E − 04
VEGF, Hypoxia, and Angiogenesis2.67E − 03
ECM-receptor interaction1.7E − 03
Actions of Nitric Oxide in the heart4.82E − 03
Cell junction organization5.75E − 02
Basal cell carcinoma2.03E − 02
Bacterial invasion of epithelial cells4.96E − 02
Small cell lung cancer5.97E − 02
Integrin cell surface interactions5.42E − 02
VEGF binds to VEGFR leading to receptor dimerization5.42E − 02
VEGF ligand-receptor interactions5.42E − 02
Cell junction organization5.75E − 02
BPsprouting angiogenesis2.66E − 02
activation of Janus kinase activity2.34E − 02
extracellular matrix assembly2.66E − 02
endothelial stalk cell fate specification2.66E − 02
lung vasculature development3.60E − 02
positive regulation of focal adhesion assembly2.48E − 02
positive regulation of endothelial cell chemotaxis7.16E − 03
collagen fibril organization2.66E − 02
positive regulation of endothelial cell proliferation4.81E − 02