Table 6 Results of the Pathway and GO Biological Process Enrichment Analysis of Several Important Consensus Modules
Consensus | Module | Pathway/BP | Term | Adjusted P-value |
|---|---|---|---|---|
asthma-IPF | Purple | Pathway | Extracellular matrix organization | 6.81E − 06 |
Degradation of the extracellular matrix | 2.84E − 02 | |||
Collagen biosynthesis and modifying enzymes | 1.48E − 02 | |||
Integrin cell surface interactions | 2.57E − 04 | |||
Collagen formation | 2.14E − 02 | |||
Syndecan interactions | 2.14E − 02 | |||
Non-integrin membrane-ECM interactions | 5.91E − 02 | |||
BP | extracellular matrix disassembly | 2.47E − 05 | ||
biofilm matrix organization | 2.47E − 05 | |||
basement membrane organization | 2.47E − 05 | |||
negative regulation of wound healing, spreading of epidermal cells | 3.49E − 02 | |||
extracellular matrix organization | 2.47E − 05 | |||
regulation of blood vessel branching | 5.56E − 02 | |||
asthma-COPD | Turquoise | Pathway | Assembly of the primary cilium | 4.21E − 02 |
BP | cilium assembly | 1.30E − 04 | ||
cilium organization | 1.30E − 04 | |||
plasma membrane bounded cell projection assembly | 6.81E − 04 | |||
cilium-dependent cell motility | 2.37E − 03 | |||
regulation of cilium movement | 2.37E − 03 | |||
COPD-IPF | Blue | Pathway | Focal adhesion | 7.89E − 05 |
Regulators of Bone Mineralization | 2.33E − 04 | |||
VEGF, Hypoxia, and Angiogenesis | 2.67E − 03 | |||
ECM-receptor interaction | 1.7E − 03 | |||
Actions of Nitric Oxide in the heart | 4.82E − 03 | |||
Cell junction organization | 5.75E − 02 | |||
Basal cell carcinoma | 2.03E − 02 | |||
Bacterial invasion of epithelial cells | 4.96E − 02 | |||
Small cell lung cancer | 5.97E − 02 | |||
Integrin cell surface interactions | 5.42E − 02 | |||
VEGF binds to VEGFR leading to receptor dimerization | 5.42E − 02 | |||
VEGF ligand-receptor interactions | 5.42E − 02 | |||
Cell junction organization | 5.75E − 02 | |||
BP | sprouting angiogenesis | 2.66E − 02 | ||
activation of Janus kinase activity | 2.34E − 02 | |||
extracellular matrix assembly | 2.66E − 02 | |||
endothelial stalk cell fate specification | 2.66E − 02 | |||
lung vasculature development | 3.60E − 02 | |||
positive regulation of focal adhesion assembly | 2.48E − 02 | |||
positive regulation of endothelial cell chemotaxis | 7.16E − 03 | |||
collagen fibril organization | 2.66E − 02 | |||
positive regulation of endothelial cell proliferation | 4.81E − 02 |