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Fig. 6 | Molecular Medicine

Fig. 6

From: microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway

Fig. 6

miR-195 could negatively regulate KLF5 expression; miR-195 was downregulated while KLF5 was upregulated in ischemic stroke. a Predicted binding site of miR-195 on the 3′-UTR of KLF5; b Luciferase activity of KLF5-Wt and KLF5-Mut determined by dual luciferase reporter gene assay; c Expression of miR-195 and KLF5 in brain tissues in MCAO models; d Protein expression of KLF5 in brain tissues in MCAO models; e relative expression of miR-195 and KLF5 in RCCNC cells in OGD models measured by RT-qPCR; f Protein expression of KLF5 in RCCNC cells in OGD models measured by western blot analysis; g Immunohistochemical staining results of KLF5 expression in brain tissues in MCAO models (400 ×); h positive rates of KLF5 protein. *, p < 0.05, compared with the control group; #, p < 0.05, compared with the blank and WT-MCAO groups; MCAO, middle cerebral artery occlusion; miR-195, microRNA-195; WT, wild type; KLF5, Kruppel-like factor 5; NC, negative control; OGD, oxygen glucose deprivation

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