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Fig. 7 | Molecular Medicine

Fig. 7

From: microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway

Fig. 7

miR-195 can inhibit the JNK signaling pathway by down-regulating KLF5 expression. a The protein band graph of JNK and phosphorylated JNK in MCAO rats measured by Western blot analysis; b Protein expression ratio of JNK/phosphorylated JNK in brain tissues in MCAO rats shown by histogram; c The protein band graph of JNK and phosphorylated JNK in RCCNC cells in OGD models measured by western blot analysis; d JNK/phosphorylated JNK protein expression ratio in RCCNC cells in OGD models shown by histogram; *, p < 0.05, compared with the control group; #, p < 0.05, compared with the blank and WT-MCAO groups; MCAO, middle cerebral artery occlusion; miR-195, microRNA-195; WT, wild type; KLF5, Kruppel-like factor 5; NC, negative control; OGD, oxygen glucose deprivation; JNK, Jun N-terminal kinase; p-JNK, phosphorylated-Jun N-terminal kinase; RT-qPCR, reverse transcription-quantitative polymerase chain reaction

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