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Fig. 8 | Molecular Medicine

Fig. 8

From: microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway

Fig. 8

miR-195 overexpression could decline the expression of KLF5 and inactivate the JNK signaling pathway, thus suppressing neuronal apoptosis. a The protein band graph of Bax and Bcl-2 in brain tissues in MCAO rats measured by western blot analysis; b Expression of Bax and Bcl-2 protein relative to GAPDH in brain tissues in MCAO rats shown by histogram; c The protein band graph of Bax and Bcl-2 in OGD cell models measured by western blot analysis; d Expression of Bax and Bcl-2 protein relative to GAPDH in OGD cell models shown by histogram; e Results of Caspase-3 activity detection; f TUNEL stained cells (400 ×); g TUNEL positive cells shown by histogram. *, p < 0.05, compared with the control group; #,p < 0.05, compared with the blank and WT-MCAO groups; MCAO, middle cerebral artery occlusion; miR-195, microRNA-195; WT, wild type; KLF5, Kruppel-like factor 5; NC, negative control; OGD, oxygen glucose deprivation; Bax, BCL2-associated X protein; Bcl-2, B cell lymphoma-2; TUNEL, TdT-mediated dUTP Nick-End Labeling

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