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Fig. 4 | Molecular Medicine

Fig. 4

From: Tracing CLL-biased stereotyped immunoglobulin gene rearrangements in normal B cell subsets using a high-throughput immunogenetic approach

Fig. 4

a Box-plots of the frequency (%) of CSB-IG rearrangements in CD5+ and CD5- B cell fractions from three PB and from three spleen samples. Each dot represents a single individual. CD5+ B cells expressed higher number of CBS-IG rearrangements (p = 0.002 PB; p = 0.01 spleens) irrespective of their location, PB or spleen. b CLL stereotyped subset distribution in the CBS-IG rearrangements of CD5+ and CD5-B cells. CLL stereotype subsets are marked by different colours as indicated. c Frequency of mutated and unmutated rearrangements in CBS-IG and in non CBS-IG rearrangements in the CD5+ and CD5-B cells as indicated

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Molecular Medicine

ISSN: 1528-3658