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Fig. 2 | Molecular Medicine

Fig. 2

From: LncRNA HULC induces the progression of osteosarcoma by regulating the miR-372-3p/HMGB1 signalling axis

Fig. 2

HULC knockdown inhibited the proliferation, migration and invasion of osteosarcoma cells in vitro. U2OS cells were transfected with HULC-targeting shRNA (sh-HULC), negative control shRNA (sh-NC), pcDNA3.1-HULC overexpression vector (pcDNA-HULC) or empty vector plasmid (pcDNA-3.1). Cell proliferation was tested by CCK-8 assay (A) and colony formation assay (B); cell apoptosis was analysed by flow cytometry (C); and cell migration and invasion were detected by wound healing assay (D) and transwell assay (E). Data are shown as the mean ± SD. * p < 0.05, ** p < 0.01

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