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Fig. 5 | Molecular Medicine

Fig. 5

From: circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling

Fig. 5

circKIF4A knockdown inhibited the Wnt/β-catenin signal pathway and regulated proliferation-related signal by targeting miR-139-3p. After transfecting A172 and LN229 cells with sh-circKIF4A, miR-139-3p mimics or miR-139-3p inhibitors, a the protein expression of Wnt5a, GSK-3β, β-catenin and p-β-catenin were detected by Western blotting. b The quantification of Wnt5a, GSK-3β, β-catenin and p-β-catenin relative protein level as a ratio to that of GAPDH (internal control). c The protein expression of c-Myc, cyclin D1, Bcl2 and Bax were detected by Western blotting. d The quantification of c-Myc, cyclin D1, Bcl2 and Bax relative protein level as a ratio to that of GAPDH (internal control). *p < 0.05, **p < 0.01, ***p < 0.001

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