Fig. 8

The metabolic networks represented in the hair metabolome of MCDA twins. a The two-dimensional network was constructed using the metabolic pathways that were significantly different between the different sIUGR clinical forms and control twins. The red circles are metabolites that were significantly different between T2&T3 sIUGR-S and Control abbreviated as C1. The blue circles are metabolites that were significantly different between T2&T3 sIUGR-L and Control abbreviated as C2. The green circles are metabolites that were significantly different between T2&T3 sIUGR-S and T1 sIUGR-S abbreviated as C3. The grey circles are metabolites that were significantly different between T1 sIUGR-S and Control abbreviated as C7. The purple circles are metabolites that were significantly different between T1 sIUGR-L and Control abbreviated as C8. Metabolites present in multiple comparisons are merged with multiple colors. The yellow circles are identified metabolites that exhibited no statistical significance. All smaller yellow circles are unidentified metabolites that were directly linked to identified metabolites. The arrowheads indicate the direction of the metabolic reactions. b A chord plot displays how metabolites with ROC curve > 0.9 participate in different significant metabolic pathways. c A chord plot displays how metabolites involved in the nervous system link to metabolic pathways