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Fig. 4 | Molecular Medicine

Fig. 4

From: Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s disease

Fig. 4

Effects of MIF deficiency in MIF-KO mice and cells, in vitro and ex vivo and in vivo. a qPCR off hippocampal cytokine expression in MIF-KO mice after ICV-STZ compared to ICV-Veh treatment. Bars represent the mean ± SEM) of 4 to 6 animals ran as duplicate technical replicates. Statistical testing was performed using Student’s t-test. b. IL-6 ELISA in STZ-treated wild type and MIF-KO astrocytes. Data is presented as means ± SEM from n = 3 biological replicates (c). Freezing in the contextual fear conditioning task of ICV- with respect to ICV-Veh treated STZ MIF-KO mice. Data are presented as mean ± SEM for n = 6 animals per group. Statistical testing was performed using Student’s t-test (*P < 0.05, n.s. - not significant)

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