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Fig. 1 | Molecular Medicine

Fig. 1

From: MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis

Fig. 1

Cobalt (II) chloride (CoCl2) in rat vascular smooth muscle cells (A7r5) inhibited angiogenesis. a Schematic of the protocol for treatment of A7r5 VSMCs with CoCl2 or medium only. b mRNA expressions of NOS3, VEGFA, CXCL12 and CXCR4 compared in cells treated with CoCl2 or medium only (n = 3). c Representative western blots depicting HIF-1α, eNOS, VEGF and CXCR4 expression in CoCl2 and medium treated cells. d Normalized expressions of HIF-1α, eNOS, VEGF and CXCR4 (n = 3). Data are presented as the means ± SEM of three independent experiments performed by triplicate, * P < 0.05; ** P < 0.01; ns, non-significance (one-way ANOVA with Tukey-Kramer post hoc test)

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