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Fig. 2 | Molecular Medicine

Fig. 2

From: MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis

Fig. 2

CoCl2 in rat vascular smooth muscle cells (A7r5) inhibited proliferation and induces senescence. a Senescence-associated-β-galactosidase staining demonstrating senescence in CoCl2 and medium treated cells. b Bar graphs show quantification of relative of SA-β-gal positive cells (n = 3). c mRNA expressions of TERT, TERF1 and TERF2 compared in cells treated with CoCl2 or medium only (n = 3). d, f Representative western blots depicting TERF1, TERF2, p16INK4, p21CIP1, pRB expression in CoCl2 and medium treated cells. e, g Normalized expressions of TERF1, TERF2, p16INK4, p21CIP1, pRB (n = 3). Data are presented as the means ± SEM.* P < 0.05; ** P < 0.01; *** P < 0.001; ns, non-significance (one-way ANOVA with Tukey-Kramer post hoc test)

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