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Fig. 7 | Molecular Medicine

Fig. 7

From: MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis

Fig. 7

Schematic diagram represents the proposed mechanism of action of microRNA-214 (miR-214) in senescent VSMCs. In response to hypoxia-induced oxidative stress, hypoxia-induced microRNA-214 were overexpresed and promoted A7r5 VSMCs enter a senescent state. In senescent VSMCs, miR-214 targeted quaking to trigger loss of telomere integrity, upregulation of the cell cycle inhibitors p16INK4 and/or p21CIP1, and accumulation of senescence-associated β-galactosidase (SA-β-Gal). Therefore, miR-214 appeared to induce VSMC senescence and cell death, further jeopardize plaque stability in carotid artery stenosis. Arrows (—>) indicated molecular interaction or relation with miR-214

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