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Fig. 1 | Molecular Medicine

Fig. 1

From: Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways

Fig. 1

Pathological changes in mice lung tissues after treatment. In this figure, mice (n = 30) were randomly divided into equal 5 groups: control, model (Bleomycin (BLM)), pirfenidone (PFD), PFD + negative control (NC), and PFD + β-catenin. a Hematoxylin-eosin (HE) staining observed the structure and inflammatory reaction in in mice lung tissues after treatment. b Masson trichrome staining was performed to view the collagen deposition in lung tissues after treatment. c, d The levels of inflammatory factors IL-6 and TNF-α in lung tissue supernatant were measured by enzyme-linked immunosorbent assay (ELISA) assay. e The content of collagen I (Col-I) in lung tissues were detected through immunohistochemistry. ***P < 0.001, vs. control; &&P < 0.01, &&&P < 0.001, vs. model; #P < 0.05, ###P < 0.001, vs. PFD + NC. N = 3

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Molecular Medicine

ISSN: 1528-3658