Table 3 IL-1B SNPs and risk of EC with or without adjustment for gender and age
SNP | Genotypes | Controls, n (%) | Cases, n (%) | Without Adjustment | With Adjustment | ||
|---|---|---|---|---|---|---|---|
OR (95% CI) | pa | OR (95% CI) | pb | ||||
rs2853550 | |||||||
 Codominant | G/G | 417 (84.1%) | 295 (76.8%) | 1.00 | 0.000 | 1.00 | 0.011 |
A/G | 71 (14.3%) | 88 (22.9%) | 1.75 (1.24–2.48) | 1.63 (1.10–2.42) | |||
A/A | 8 (1.6%) | 1 (0.3%) | 0.18 (0.02–1.42) | 0.22 (0.03–1.86) | |||
 Dominant (ref: G/G) | A/G + A/A | 79 (15.9%) | 89 (23.2%) | 1.59 (1.14–2.23) | 0.007 | 1.49 (1.02–2.18) | 0.041 |
 Recessive (ref: G/G + A/G) | A/A | 8 (1.6%) | 1 (0.3%) | 0.16 (0.02–1.28) | 0.032 | 0.20 (0.02–1.70) | 0.082 |
 Log-additive | – | – | – | 1.38 (1.01–1.89) | 0.042 | 1.30 (0.92–1.85) | 0.140 |
rs3136558 | |||||||
 Codominant | A/A | 197 (39.7%) | 140 (36.6%) | 1.00 | 0.620 | 1.00 | 0.980 |
G/A | 227 (45.8%) | 181 (47.4%) | 1.12 (0.84–1.50) | 0.97 (0.70–1.35) | |||
G/G | 72 (14.5%) | 61 (16.0%) | 1.19 (0.80–1.79) | 1.01 (0.64–1.59) | |||
 Dominant (ref: A/A) | G/A + G/G | 299 (60.3%) | 242 (63.4%) | 1.14 (0.87–1.50) | 0.350 | 0.98 (0.72–1.34) | 0.910 |
 Recessive (ref: A/A + G/A) | G/G | 72 (14.5%) | 61 (16.0%) | 1.12 (0.77–1.62) | 0.550 | 1.02 (0.67–1.56) | 0.920 |
 Log-additive | – | – | – | 1.10 (0.91–1.33) | 0.340 | 1.00 (0.80–1.24) | 0.980 |
rs1143630 | |||||||
 Codominant | G/G | 352 (70.5%) | 278 (72.4%) | 1.00 | 0.360 | 1.00 | 0.220 |
G/T | 135 (27.1%) | 92 (24.0%) | 0.86 (0.63–1.17) | 0.82 (0.58–1.17) | |||
T/T | 12 (2.4%) | 14 (3.6%) | 1.48 (0.67–3.24) | 1.74 (0.72–4.17) | |||
 Dominant (ref: G/G) | G/T + T/T | 147 (29.5%) | 106 (27.6%) | 0.91 (0.68–1.23) | 0.550 | 0.89 (0.64–1.25) | 0.510 |
 Recessive (ref: G/G + G/T) | T/T | 12 (2.4%) | 14 (3.6%) | 1.54 (0.70–3.36) | 0.280 | 1.83 (0.77–4.36) | 0.170 |
 Log-additive | – | – | – | 0.98 (0.76–1.26) | 0.860 | 0.98 (0.74–1.31) | 0.910 |
rs1143627 | |||||||
 Codominant | A/A | 124 (25.1%) | 111 (30.6%) | 1.00 | 0.170 | 1.00 | 0.580 |
A/G | 266 (54.0%) | 175 (48.2%) | 0.73 (0.53–1.01) | 0.87 (0.61–1.25) | |||
G/G | 103 (20.9%) | 77 (21.2%) | 0.84 (0.56–1.23) | 1.05 (0.68–1.64) | |||
 Dominant (ref: A/A) | A/G + G/G | 369 (74.8%) | 252 (69.4%) | 0.76 (0.56–1.03) | 0.080 | 0.92 (0.65–1.30) | 0.640 |
 Recessive (ref: A/A + G/A) | G/G | 103 (20.9%) | 77 (21.2%) | 1.02 (0.73–1.42) | 0.910 | 1.15 (0.79–1.68) | 0.470 |
 Log-additive | – | – | – | 0.90 (0.74–1.09) | 0.290 | 1.01 (0.81–1.27) | 0.900 |
rs16944 | |||||||
 Codominant | G/G | 128 (25.6%) | 115 (30.0%) | 1.00 | 0.270 | 1.00 | 0.570 |
G/A | 269 (53.9%) | 187 (48.8%) | 0.77 (0.57–1.06) | 0.90 (0.63–1.28) | |||
A/A | 102 (20.4%) | 81 (21.1%) | 0.88 (0.60–1.30) | 1.11 (0.72–1.71) | |||
 Dominant (ref: G/G) | G/A + A/A | 371 (74.3%) | 268 (70.0%) | 0.80 (0.60–1.08) | 0.150 | 0.96 (0.68–1.34) | 0.790 |
 Recessive (ref: G/G + G/A) | A/A | 102 (20.4%) | 81 (21.1%) | 1.04 (0.75–1.45) | 0.800 | 1.18 (0.82–1.72) | 0.370 |
 Log-additive | – | – | – | 0.93 (0.76–1.12) | 0.440 | 1.04 (0.84–1.29) | 0.720 |
rs1143623 | |||||||
 Codominant | C/C | 171 (34.5%) | 154 (40.9%) | 1.00 | 0.150 | 1.00 | 0.280 |
C/G | 254 (51.2%) | 173 (45.9%) | 0.76 (0.57–1.01) | 0.79 (0.57–1.10) | |||
G/G | 71 (14.3%) | 50 (13.3%) | 0.78 (0.51–1.19) | 1.05 (0.65–1.70) | |||
 Dominant (ref: C/C) | C/G + G/G | 325 (65.5%) | 223 (59.1%) | 0.76 (0.58–1.00) | 0.054 | 0.84 (0.62–1.15) | 0.280 |
 Recessive (ref: C/C + C/G) | G/G | 71 (14.3%) | 50 (13.3%) | 0.92 (0.62–1.35) | 0.660 | 1.19 (0.76–1.87) | 0.440 |
 Log-additive | – | – | – | 0.85 (0.70–1.04) | 0.110 | 0.96 (0.76–1.20) | 0.700 |