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Table 3 IL-1B SNPs and risk of EC with or without adjustment for gender and age

From: IL-1B rs2853550 polymorphism contributes to esophageal cancer susceptibility in Chinese Han population of Northwest China

SNP Genotypes Controls, n (%) Cases, n (%) Without Adjustment With Adjustment
OR (95% CI) pa OR (95% CI) pb
rs2853550
 Codominant G/G 417 (84.1%) 295 (76.8%) 1.00 0.000 1.00 0.011
A/G 71 (14.3%) 88 (22.9%) 1.75 (1.24–2.48) 1.63 (1.10–2.42)
A/A 8 (1.6%) 1 (0.3%) 0.18 (0.02–1.42) 0.22 (0.03–1.86)
 Dominant (ref: G/G) A/G + A/A 79 (15.9%) 89 (23.2%) 1.59 (1.14–2.23) 0.007 1.49 (1.02–2.18) 0.041
 Recessive (ref: G/G + A/G) A/A 8 (1.6%) 1 (0.3%) 0.16 (0.02–1.28) 0.032 0.20 (0.02–1.70) 0.082
 Log-additive 1.38 (1.01–1.89) 0.042 1.30 (0.92–1.85) 0.140
rs3136558
 Codominant A/A 197 (39.7%) 140 (36.6%) 1.00 0.620 1.00 0.980
G/A 227 (45.8%) 181 (47.4%) 1.12 (0.84–1.50) 0.97 (0.70–1.35)
G/G 72 (14.5%) 61 (16.0%) 1.19 (0.80–1.79) 1.01 (0.64–1.59)
 Dominant (ref: A/A) G/A + G/G 299 (60.3%) 242 (63.4%) 1.14 (0.87–1.50) 0.350 0.98 (0.72–1.34) 0.910
 Recessive (ref: A/A + G/A) G/G 72 (14.5%) 61 (16.0%) 1.12 (0.77–1.62) 0.550 1.02 (0.67–1.56) 0.920
 Log-additive 1.10 (0.91–1.33) 0.340 1.00 (0.80–1.24) 0.980
rs1143630
 Codominant G/G 352 (70.5%) 278 (72.4%) 1.00 0.360 1.00 0.220
G/T 135 (27.1%) 92 (24.0%) 0.86 (0.63–1.17) 0.82 (0.58–1.17)
T/T 12 (2.4%) 14 (3.6%) 1.48 (0.67–3.24) 1.74 (0.72–4.17)
 Dominant (ref: G/G) G/T + T/T 147 (29.5%) 106 (27.6%) 0.91 (0.68–1.23) 0.550 0.89 (0.64–1.25) 0.510
 Recessive (ref: G/G + G/T) T/T 12 (2.4%) 14 (3.6%) 1.54 (0.70–3.36) 0.280 1.83 (0.77–4.36) 0.170
 Log-additive 0.98 (0.76–1.26) 0.860 0.98 (0.74–1.31) 0.910
rs1143627
 Codominant A/A 124 (25.1%) 111 (30.6%) 1.00 0.170 1.00 0.580
A/G 266 (54.0%) 175 (48.2%) 0.73 (0.53–1.01) 0.87 (0.61–1.25)
G/G 103 (20.9%) 77 (21.2%) 0.84 (0.56–1.23) 1.05 (0.68–1.64)
 Dominant (ref: A/A) A/G + G/G 369 (74.8%) 252 (69.4%) 0.76 (0.56–1.03) 0.080 0.92 (0.65–1.30) 0.640
 Recessive (ref: A/A + G/A) G/G 103 (20.9%) 77 (21.2%) 1.02 (0.73–1.42) 0.910 1.15 (0.79–1.68) 0.470
 Log-additive 0.90 (0.74–1.09) 0.290 1.01 (0.81–1.27) 0.900
rs16944
 Codominant G/G 128 (25.6%) 115 (30.0%) 1.00 0.270 1.00 0.570
G/A 269 (53.9%) 187 (48.8%) 0.77 (0.57–1.06) 0.90 (0.63–1.28)
A/A 102 (20.4%) 81 (21.1%) 0.88 (0.60–1.30) 1.11 (0.72–1.71)
 Dominant (ref: G/G) G/A + A/A 371 (74.3%) 268 (70.0%) 0.80 (0.60–1.08) 0.150 0.96 (0.68–1.34) 0.790
 Recessive (ref: G/G + G/A) A/A 102 (20.4%) 81 (21.1%) 1.04 (0.75–1.45) 0.800 1.18 (0.82–1.72) 0.370
 Log-additive 0.93 (0.76–1.12) 0.440 1.04 (0.84–1.29) 0.720
rs1143623
 Codominant C/C 171 (34.5%) 154 (40.9%) 1.00 0.150 1.00 0.280
C/G 254 (51.2%) 173 (45.9%) 0.76 (0.57–1.01) 0.79 (0.57–1.10)
G/G 71 (14.3%) 50 (13.3%) 0.78 (0.51–1.19) 1.05 (0.65–1.70)
 Dominant (ref: C/C) C/G + G/G 325 (65.5%) 223 (59.1%) 0.76 (0.58–1.00) 0.054 0.84 (0.62–1.15) 0.280
 Recessive (ref: C/C + C/G) G/G 71 (14.3%) 50 (13.3%) 0.92 (0.62–1.35) 0.660 1.19 (0.76–1.87) 0.440
 Log-additive 0.85 (0.70–1.04) 0.110 0.96 (0.76–1.20) 0.700
  1. SNP Single nucleotide polymorphism, OR Odd ratio, 95% CI 95% confidence interval, Ref Reference category
  2. pa: p-values calculated by logistic regression analysis
  3. pb: p-values calculated by logistic regression analysis with adjustments for gender and age
  4. Bold italics indicates the SNP with statistical significance (p < 0.05)