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Fig. 5 | Molecular Medicine

Fig. 5

From: A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients

Fig. 5

Molecular dynamics analysis of wt-type TP53 and mTP53 (p.A138V). Comparison of RMSF and RMSD plot between wild type and mutant (p.A138V) Tp53 protein. a The plot represents the time dependent RMSF plot of the TP53 DNA binding domain of wild type and p.A138V mutant respectively. Residue 91–291of Tp53 protein represents the DNA binding domain/core domain of Tp53 crystal structure 4HJE.With respect to residues mapped in Tp53 protein, different loops and helixes were denoted like L1 loop (residues 112–124), L2 loop (residues 164–194) (interrupted by Helix H1 residues 163–178), and L3 loop (residues 239–251). b The plot represents the time dependent RMSD plot for backbone, side chains and heavy atoms of the TP53 DNA binding domain of wild type (left) and TP53p.A138V mutant (right)

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