Cohort | Total KRAS Mutation Identified (Codon 12 & 61) | Method | Tumour Type | KRAS Mutation Frequency | Total KRAS mutation Frequency |
---|---|---|---|---|---|
Discovery Cohort (n = 8) | N = 1 | NGS | PDAC (n = 5) | 0% | 12% |
PAC (n = 3) | 33% (n = 1) | ||||
Validation Cohort (n = 85)/ (n = 75)a | N = 16 | Sanger Sequencing | PDAC (n = 25) | 32%(n = 8) | 19% |
PAC (n = 50) | 14% (n = 6) | ||||
PCR-RFLP of 12th Codon | PDAC (n = 25) | 32%(n = 8) | 19% | ||
PAC (n = 50) | 14% (n = 6) | ||||
ASPCR | PDAC (n = 25) | 36%(n = 9) | 20% | ||
PAC (n = 50) | 12% (n = 6) | ||||
Independent Patient Cohort (n = 24) | N = 8 | PCR-RFLP of 12th Codon | PDAC (n = 24) | 33% (n = 8) | 33% |