Fig. 4

CQ reduces hindlimb perfusion recovery after femoral artery ligation (FAL). a Laser Doppler Perfusion Imaging (LDPI) of C57Bl6/J (WT) and caspase-1/11KO treated with either CQ or PBS (control) over the course of the study. LDPI was performed just before ligation (Day 0), and 1, 7, 14 and 21 days after FAL on the right hindlimb (screen left on each image). Representative images shown. LDPI in each animal expressed as a ratio of perfusion in ischemic to the nonischemic limb in. bN = 7 WT mice/experimental group;*p < 0.01; **p < 0.001, and in (c) *p < 0.01; *p < 0.0001; ***p < 0.05 N = 4 KO mice/experimental group