Fig. 5

CQ reduces fibrosis and fat replacement in WT but not caspase-1/11KO mice. (a and c) Hematoxylin and eosin, and (b and d) Masson’s trichrome staining of tibialis anterior muscles from C57Bl6/J (WT) mice and caspase-1/11KO mice at 21 days after femoral artery ligation (FAL) and subsequent treatment with either PBS (control) or CQ (50 mg/kg) regenerating myofiber cross sectional area (CSA; arrow), fat replacement (arrowhead) and fibrosis (blue), respectively. e Quantification of CSA; *p = 0.003 PBS:CQ in WT; (f) Quantification of fat/fibrotic replacement of muscle tissue; **p < 0.001, PBS:CQ in WT. Representative images shown. N = 4–5 mice per experimental group