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Fig. 6 | Molecular Medicine

Fig. 6

From: Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine

Fig. 6

Loss of caspase1/11 favors regeneration of fast over slow twitch myofibers. Myosin heavy chain (MHC) specific for either fast or slow twitch myofibers in tibialis anterior (TA) muscle from C57Bl/6 J (WT) and caspase-1/11KO mice at 21 days after femoral artery ligation (FAL) treated subsequently with PBS (control) or CQ (50 mg/kg) (upper images); Quantification of fast and slow myofibers expressed as a fraction of total number of regenerating myocytes. Four images were analyzed per limb per animal. *p < 0.05, fast fibers in PBS in WT:KO, slow fibers in PBS:CQ in KO; **p < 0.001 slow fibers in PBS in WT:KO, slow fibers in CQ in WT:KO. N = 4 mice per strain per treatment group; Scale bar = 10 μm

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