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Fig. 4 | Molecular Medicine

Fig. 4

From: Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production

Fig. 4

Ghrelin and GH in combination correct the levels of circulating monocytes and basophils in aged rats with sepsis. Rats were subjected to sham or CLP operation and treated with vehicle (normal saline) or GG (ghrelin 80 nmol/kg, GH 50 μg/kg) at 5 h after CLP. In an additional group of rats, vagotomy was performed at the time of CLP and treated with GG at 5 h after CLP. Blood was collected at 20 h after CLP. Circulating (a, b) monocytes and (c, d) basophils were measured using a hematology analyzer. Data are expressed as mean ± SEM (n = 4–6 rats/group). *P < 0.05 vs. sham; #P < 0.05 vs. CLP with vehicle treatment; †P < 0.05 vs. CLP with GG treatment

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