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Fig. 5 | Molecular Medicine

Fig. 5

From: Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production

Fig. 5

Ghrelin and GH in combination inhibit PD-1 and increase HLA-DR expression in the spleen of aged rats with sepsis. Rats were subjected to sham or CLP operation and treated with vehicle (normal saline) or GG (ghrelin 80 nmol/kg, GH 50 μg/kg) at 5 h after CLP. In an additional group of rats, vagotomy was performed at the time of CLP and treated with GG at 5 h after CLP. Spleens were harvested at 20 h after CLP. The expression of PD-1 and HLA-DR in the spleen were evaluated by immunohistochemical staining. The representative images are shown. Each group contains n = 4 spleens from 4 mice. Original magnification of images is 200 ×

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Molecular Medicine

ISSN: 1528-3658