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Fig. 4 | Molecular Medicine

Fig. 4

From: Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic reticulum stress via enhancing autophagy in rats

Fig. 4

mTOR/4E-BP1 signaling pathway was involved in the protective effect of EA against insulin resistance. The mRNA expression of PGC-1α (a) and PPARγ (b) in skeletal muscle tissues was assessed by real-time PCR. c-f The protein levels of PPARγ, PGC-1α, p-mTOR, mTOR, p-4E-BP1 and 4E-BP1 in skeletal muscle tissues were evaluated by Western blotting. The experimental data are presented as mean ± standard deviation (n = 6). * P < 0.05, ** P < 0.01, *** P < 0.001, vs the indicated group. EA, electroacupuncture; PPARγ, peroxisome proliferator-activated receptor gamma; PGC-1α, PPARγcoactivator-1α. mTOR, mechanistic target of rapamycin; 4E-BP1, 4E-binding protein 1

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Molecular Medicine

ISSN: 1528-3658