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Table 4 Diagnostic performances of serum miR-223 and APRIL to discriminate RA patients from healthy controls

From: Serum a proliferation-inducing ligand and MicroRNA-223 are associated with rheumatoid arthritis: diagnostic and prognostic implications

miRNA AUC (95%CI) P value Best cutoff value Sensitivity % Specificity % PPV % NPV %
miR-223 0.85 (0.79 to 0.91) < 0.0001 > 2.5 fold 80 95.38 94.11 83.78
APRIL 1* (1 to 1) < 0.0001 > 4.19 ng/ml 100 100 100 100
  1. PPV Positive predictive value, NPV negative predictive value. *significant difference between AUCs, P < 0.0001. RA, n = 120; healthy controls, n = 130